top of page
Picture origami ribbons_edited.jpg

Drug Interactions

Special considerations when using MSCs in joints, tendons and ligaments

 

  • MSCs primarily act by modulating the immune system

  • When planning a treatment, do not use any agents that might inhibit or interfere with the inflammatory response, including antibiotics. These are cytotoxic and Inhibit proliferation and function

  • Allow a 5-day washout period prior to MSC treatment

  • Use sterile technique to prepare the joint for injection

  • In the event of a flare-up, ice joint/ligament/tendon, monitor over 3-5 days.

  • When treating soft tissue, PRP is always recommended as an additive as it provides a biological scaffold and releases growth factors

  • When blocking – Marcaine is severely chondrotoxic

Use Naropin > Procaine > Lignocaine

Treatment can be done within 24hrs after block

USE THESE NOT THESE

PHOTsO-2023-02-12-18-05-20.png
PHOTO-2023-02-12-18-05-20.png

References

  1. Barrachina, L., Remacha, A.R., Romero, A., Vitoria, A., Albareda,, J., Prades, M., et al. 2018. Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritis. BMC Vet Res. 14(241):doi.org/10.1186/s12917-018-1556-3.

  2. Broeckx, S., Suls, M., Beerts, C., Vandenberghe, A., Seys, B., Wuertz-Kozak, K., et al. 2014. Allogenic mesenchymal stem cells as a treatment for equine degenerative joint disease: a pilot study. Curr Stem Cell Res Ther. 9(6):497-503

  3. Chen, X., Gan, Y., Li, W., Su, J., Zhang, Y., Huang, Y. et al. 2014. The interaction between mesenchymal stem cells and steroids during inflammation.: Cell Death Dis. (2014)5:e1009; doi:10.1038/cddis.2013.537

  4. Da Silva Meirelles, L., Chagastelles, P.C., Nardi, N.B. 2006. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J. Cell Sci. 119(11):2204–2213.

  5. Edmonds, R. E., Garvican, E. R., Smith, R. K. W., Dudhia J. 2017. Influence of commonly used pharmaceutical agents on equine bone marrow-derived mesenchymal stem cell viability Equine Vet J. 49(3):352-357.

  6. Fernández-Francos S, Eiro N, Costa LA, Escudero-Cernuda S, Fernández-Sánchez ML, Vizoso FJ. Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine. International Journal of Molecular Sciences. 2021; 22(7):3576.

  7. Freitag, J., Bates, D., Boyd, R., Shah, K., Barnard, A., Huguenin, L., et al. 2016. Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review. BMC Musculoskel Dis.17:230.

  8. Fu, Y., Karbaat, L., Wu, L., Leijten, J., Both, S.K., Karperien, M. 2017. Trophic effects of mesenchymal stem cells in tissue regeneration. Tissue Eng Part B Rev. Dec;23(6):515-528. doi: 10.1089/ten.TEB.2016.0365.

  9. Gugjoo, M. B., & Sharma, G. T. (2019). Equine mesenchymal stem cells: properties, sources, characterization, and potential therapeutic applications. Journal of equine veterinary science, 72, 16-27.

  10. Hammoodi, O.T., Kareem, M. H., & Hassan, M. S. 2020. A Review in Regenerative Medicine: A Modern Therapy in Horses. International Journal of Pharmaceutical Research, 12(1).

  11. Kong, L., Zheng, L.Z., Qin, L., Ho, K.K.W. 2017. Role of mesenchymal stem cells in osteoarthritis treatment. J Orthop Trans. 9:89–103.

  12. Leibacher, J. & Henschler, R. 2016. Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells. Stem Cell Res. Ther. 7(7):doi 10.1186/s13287-015-0271-2

  13. MacDonald, E. S., & Barrett, J. G. (2020). The potential of mesenchymal stem cells to treat systemic inflammation in horses. Frontiers in Veterinary Science, 6, 507.

  14. Mao, A.S. & Mooney, D.J. 2015. Regenerative medicine: Current therapies and future directions. Proceedings of the National Academy of Sciences 112(47):14452-14459, https://doi.org/10.1073/pnas.1508520112

  15. Otto, W.R. & N.A. Wright. 2011. Mesenchymal stem cells: from experiment to clinic. Fibrogenesis Tissue Repair. 4:20.

  16. Patel, D.M., Shah, J., Srivastava, AS. 2013. Therapeutic potential of mesenchymal stem cells in regenerative medicine.  Stem cells international 2013 (2013).

bottom of page